2024
2023
Namoto, K., Baader C., Orsini V., LandShammer A., Breuer E., Dinh K.T., Ungricht R., Pikiolek M., Laurent S., Lu B., Aebi A., Schönberger K., Vangrevelinghe E., Evrova O., Sun T., Annunziato S., Lachal J., Redmond E., Wang L., Wetzel K., Capodieci P., Turner J., Schutzius G., Unterreiner V., Trunzer M., Buschmann N., Behnke D., Machauer R., Scheufler C., Parker C., Ferro M., Grevot A., Beyerbach A., Lu W, Forbes S., Wagner J., Bouwmeester T., Liu J., Sohal B., Sahambi S., Greenbaum L., Lohmann F., Hoppe P., Cong F., Sailer A.W., Ruffner H., Glatthar R., Humar B., Clavien P., Dill M.T., George E., Maibaum J., Liberali P., Tchorz J.S. NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo. Cell Stem Cell (2024)
Moos, F., Suppinger, S., de Medeiros, G., Oost, K., Boni, A., Rémy, C., Weevers, S., Tsiairis, C., Strnad, P., Liberali, P. Open top multisample dual-view light-sheet microscope for live imaging of large multicellular systems. Nature Methods (2024)
Schwayer, C., Brückner, D. Connecting theory and experiment in cell and tissue mechanics. J Cell Sci (2023)
Oost, K., Kahnwald, M., Barbiero, S., de Medeiros, G., Kalck, V., Challet Meylan, L., Smallwood, S., Stadler, M., Liberali, P. Dynamics and plasticity of stem cells in the regenerating human colonic epithelium. BiorXiv (2023)
Moos, F., Suppinger, S., de Medeiros, G., Oost, K., Boni, A., Rémy, C., Weevers, S., Tsiairis, C., Strnad, P., Liberali, P. Open top multi sample dual view light sheet microscope for live imaging of large multicellular systems. BiorXiv (2023)
Suppinger, S., Zinner, M., Aizarani, N., Lukonin, I., Ortiz, R., Azzi, C., B Stadler, M., Vianello, S., Palla, G., Kohler, H., Mayran, A., P Lutolf, M., Liberali, P. Multimodal characterization of murine gastruloid development. Cell Stem Cell Volume 30, Issue 6, 1 June 2023, Pages 867-884.e11 (2023)
de Medeiros, G., Ortiz, R., Strnad, P., Boni, A., Moos, F., Repina, N., Chalet-Meylan, L., Maurer, F., Liberali, P. (2022). Multiscale light-sheet organoid imaging framework. Nature communications, 13(1), 1-14 (2022).
Azkanaz M, Corominas-Murtra B, Ellenbroek S, Bruens L, Webb A, Laskaris D, Oost K, Lafirenze A, Annusver K, Messal H, Iqbal S, Flanagan D, Huels D, Rojas-Rodríguez F, Vizoso M, Kasper M, Sansom O, Snippert H, Liberali P, Simons B, Katajisto P, Hannezo E, van Rheenen J. Retrograde movements determine effective stem cell numbers in the intestine. Nature 607, pages548–554 (2022)
Heinz, M.C., Peters, N.A., Oost, K.C., GH Lindeboom, R., van Voorthuijsen, L., Fumagalli, A., van der Net, M.C., de Medeiros, G., Hageman, J.H., Verlaan-Klink, I., Borel Rinkes, I.H.M., Liberali,P., Gloerich, M., van Rheenen, J., Vermeulen, M., Kranenburg, O., Snippert, H.J.G., Liver colonization by colorectal cancer metastases requires YAP-controlled plasticity at the micrometastatic stage. Cancer Research Volume 82, Issue 10, May (2022)
Gjorevski N, Nikolaev M, Brown TE, Mitrofanova O, Brandenberg N, Delrio FW, Yavitt FM, Liberali P, Anseth KS, Lutolf MP. Tissue geometry drives deterministic organoid patterning. Science 375 (6576), eaaw90217 (2022)
Yang Q & Liberali P. Adaptive differentiation for fast barrier restoration. Dev Cell. 57, 147-148 (2022)
2022
Lukonin I, Zimmer M, Liberali P. Organoids in image-based phenotypic chemical screens. Exp Mol Med. 53, 1495-1502 (2021).
Yang Q & Liberali P. Collective behaviours in organoids. Curr. Opin. Cell Biol. 72, 81–90 (2021).
Yang Q*, Xue SL*, Rempfler M, Vischi D, Maurer-Gutierrez F, Hiiragi T, Hannezo E, Liberali P. Cell fate coordinates mechano-osmotic forces in intestinal crypt formation. Nature Cell Biology 23, pages 733–744 (2021)
de Medeiros G, Ortiz R, Strnad P, Boni A, Maurer F, Liberali P. Multiscale light-sheet organoid imaging framework. bioRxiv 2021.05.12.443427; doi: https://doi.org/10.1101/2021.05.12.443427
Bock C, Boutros M, Camp JG, Clarke L, Clevers H, Knoblich JA, Liberali P, Regev A, Rios AC, Stegle O, Stunnenberg HG, Teichmann SA, Treutlein B, Vries RGJ, the Human Cell Atlas ‘Biological Network’ Organoids. The Organoid Cell Atlas. Nature Biotechnology 39, pages 13-17 (2021)
2021
Lukonin I, Serra D, Challet Meylan L, Volkmann K, Baaten J, Zhao, R Meeusen S, Colman K, Maurer F, Stadler MB, Jenkins J, Liberali P. Phenotypic landscape of intestinal organoid regeneration. Nature 586, pages 275–280 (2020)
Zinner M*, Lukonin I*, Liberali P. Design principles of tissue organisation: How single cells coordinate across scales. Current Opinion in Cell Biology 67, pages 37-45 (2020)
Yang Q, Xue SL, Chan CJ, Rempfler M, Vischi M, Maurer-Gutierrez F, Hiiragi T, Hannezo E, Liberali P. Cell fate coordinates mechano-osmotic forces in intestinal crypt morphogenesis. bioRxiv 2020.05.13.094359 doi: https://doi.org/10.1101/2020.05.13.094359
Yang Q, Oost KC, Liberali P. Engineering human knock-in organoids. Nat Cell Biol. 22, 261–263 https://doi.org/10.1038/s41556-020-0478-z
2020
Mayr U*, Serra D*, Liberali P. Exploring single cells in space and time during tissue development, homeostasis and regeneration. Development. 2019 Jun 27. 146(12).
Serra D*, Mayr U*, Boni A*, Lukonin I, Rempfler M, Challet Meylan L, Stadler MB, Strnad P, Papasaikas P, Vischi D, Waldt A, Roma G, Liberali P. Self-organization and symmetry breaking in intestinal organoid development. Nature. doi: 10.1038/s41586-019-1146-y.
Welling M, Mohr MA, Ponti A, Rullan Sabater L, Boni A, Kawamura YK, Liberali P, Peters AH, Pelczar P, Pantazis P. Primed Track, high-fidelity lineage tracing in mouse pre-implantation embryos using primed conversion of photoconvertible proteins. Elife. doi: 10.7554/eLife.44491.
2019
Xavier da Silveira Dos Santos A, Liberali P. From single cells to tissue self-organization. FEBS J. doi: 10.1111/febs.14694.
2018
Ballmer BA, Moos R, Liberali P, Pelkmans L, Hornemann S, Aguzzi A. Modifiers of prion protein biogenesis and recycling identified by a highly parallel endocytosis kinetics assay. J Biol Chem. 292(20), 8356-8368.
2017
2015
Gut G, Tadmor MD, Pe'er D, Pelkmans L, Liberali P. Trajectories of cell-cycle progression from fixed cell populations. Nat Methods. 12(10), 951-4.
Bologna S, Altmannova V, Valtorta E, Koenig C, Liberali P, Gentili C, Anrather D, Ammerer G, Pelkmans L, Krejci L, Ferrari S. (2015) Sumoylation regulates EXO1 stability and processing of DNA damage. Cell Cycle. 14(15), 2439-50.
Liberali P, Snijder B, Pelkmans L. Single-cell and multivariate approaches in genetic perturbation screens. Nat Rev Genet, 16, 18-32.
2014
Liberali P*, Snijder B, Pelkmans L* A hierarchical map of regulatory genetic interactions in membrane trafficking. Cell, 157, 1473-87.
*corresponding authors
2013
Snijder B, Liberali P, Frechin M, Stoeger T, Pelkmans L Predicting functional gene interactions with the hierarchical interaction score. Nat Methods, 10, 1089-92.
Colanzi A, Grimaldi G, Catara G, Valente C, Cericola C, Liberali P, Ronci M, Lalioti VS, Bruno A, Beccari AR, Urbani A, De Flora A, Nardini M, Bolognesi M, Luini A, Corda D. Molecular mechanism and functional role of brefeldin A-mediated ADP-ribosylation of CtBP1/BARS. Proc Natl Acad Sci U S A. 110(24), 9794-9.
2012
Liberali P, Pelkmans L. Towards quantitative cell biology. Nat Cell Biol, 14, 1233.
Snijder B, Sacher R, Rämö P, Liberali P, Mench K, Wolfrum N, Burleigh L, Scott CC, Verheije MH, Mercer J, Moese S, Heger T, Theusner K, Jurgeit A, Lamparter D, Balistreri G, Schelhaas M, De Haan CA, Marjomäki V, Hyypiä T, Rottier PJ, Sodeik B, Marsh M, Gruenberg J, Amara A, Greber U, Helenius A, Pelkmans L. Single-cell analysis of population context advances RNAi screening at multiple levels. Mol Syst Biol. 24(8), 579.
2009
Snijder B, Sacher R, Rämö P, Damm EM, Liberali P, Pelkmans L Population context determines cell-to-cell variability in endocytosis and virus infection. Nature, 461, 520-3.
2008
Liberali P, Rämö P, Pelkmans L. Protein kinases: starting a molecular systems view of endocytosis. Annu Rev Cell Dev Biol, 24, 501-23.
Karjalainen M, Kakkonen E, Upla P, Paloranta H, Kankaanpää P, Liberali P, Renkema GH, Hyypiä T, Heino J, Marjomäki V. A Raft-derived, Pak1-regulated entry participates in alpha2beta1 integrin-dependent sorting to caveosomes. Mol Biol Cell. 19(7), 2857-69.
Liberali P, Kakkonen E, Turacchio G, Valente C, Spaar A, Perinetti G, Böckmann RA, Corda D, Colanzi A, Marjomaki V, Luini A. The closure of Pak1-dependent macropinosomes requires the phosphorylation of CtBP1/BARS. EMBO J. 27(7), 970-81.
Baciocchi E, Giacco TD, Elisei F, Gerini MF, Lapi A, Liberali P, Uzzoli B. Steady-state and laser flash photolysis study of the carbon-carbon bond fragmentation reactions of 2-arylsulfanyl alcohol radical cations. J Org Chem. 69(24), 8323-30.
2004
Baciocchi E, Del Giacco T, Elisei F, Gerini MF, Guerra M, Lapi A, Liberali P. Electron transfer and singlet oxygen mechanisms in the photooxygenation of dibutyl sulfide and thioanisole in MeCN sensitized by N-methylquinolinium tetrafluoborate and 9,10-dicyanoanthracene. The probable involvement of a thiadioxirane intermediate in electron transfer photooxygenations. J Am Chem Soc. 125(52), 16444-54.